Genetic regulation of resistance to intracellular pathogens
作者： Emil Skamene , Philippe Gros , Adrien Forget , Patricia A. L. Kongshavn , Carole St Charles
DOI: 10.1038/297506A0
关键词: Allele 、 Mycobacterium bovis 、 Biology 、 Genetics 、 Leishmania donovani 、 Gene 、 Salmonella 、 Locus (genetics) 、 Intracellular parasite 、 Chromosome
摘要: Natural resistance of mice to infections with Salmonella typhimurium and Leishmania donovani is regulated by chromosome 1 gene(s) designated Ity Lsh, respectively1,2. Given the fact that these two microorganisms are taxonomically antigenically distinct, yet host response them same locus or complex3,4, one might expect other intracellular pathogens would be controlled similarly. Innate inbred infection Mycobacterium bovis (BCG) a single, dominant, autosomal gene Bcg which known exist in allelic forms: resistant Bcgr susceptible Bcgs (ref. 5). The distribution alleles, among total 14 38 recombinant (BXD BXH) strains, matches exactly established for alleles Lsh (gene controlling donovani) typhimurium), suggesting all locus. existence such chromosomal further supported Bcg–Lsh Bcg–Ity linkage as formal backcross analysis.
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