A literature review of biosensors for multiple sclerosis: Towards personalized medicine and point-of-care testing.

摘要: Abstract Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to severe motor and sensory deficits in patients. Although some biomolecules serum or cerebrospinal fluid have been suggested as biomarkers for MS diagnosis, following activity monitoring treatment response, most these potential are not currently clinical use available all The reasons behind this generally related insufficient robustness biomarker technical difficulties, high prices, requirements personnel their detection. Point-of-care testing (POCT) an emerging field healthcare can be applied at hospital well home without need centralized laboratory. Biosensor devices offer convenient means POCT. A biosensor compact analytical device uses bioreceptor, such antibody, enzyme, oligonucleotide, capture analyte interest. interaction between bioreceptor sensed transduced into suitable signal by transducer. advantages using detecting biomolecule interest include speed, simplicity, accuracy, relatively lower cost, lack highly qualified perform testing. Owing with help innovations development technologies, there has great developing recent years. Hence, purpose review was provide researchers up-to-date summary literature highlight challenges opportunities translational research field. In addition, because interdisciplinary study, potentially concerning specialists, neurologists, biomedical researchers, engineers, another aim bridge gap disciplines.