Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in Men

摘要: OBJECTIVE To investigate the relation between obesity, fat distribution, and weight gain through adulthood risk of non-insulin-dependent diabetes melli-tus (NIDDM). RESEARCH DESIGN AND METHODS We analyzed data from a cohort 51,529 U.S. male health professionals, 40-75 years age in 1986, who completed biennial questionnaires sent out 1988, 1990, 1992. During 5 follow-up (1987-1992), 272 cases NIDDM were diagnosed among men without history diabetes, heart disease, cancer 1986 provided complete information. Relative risks (RRs) associated with different anthropometrie measures calculated controlling for age, multivariate RRs smoking, family age. RESULTS found strong positive association overall obesity as measured by body mass index (BMI) diabetes. Men BMI ≥35 kg/m 2 had RR 42.1 (95% confidence interval [CI] 22.0-80.6) compared . at 21 absolute throughout also significant independent factors Fat waist-to-hip ratio (WHR), was good predictor only top 5%, while waist circumference positively 20% cohort. CONCLUSIONS These suggest that may be better indicator than WHR relationship abdominal adiposity Although early adulthood, predictors attained dominant factor NIDDM; even average relative significantly elevated RRs.