Inclusion of nonrandomized studies in Cochrane systematic reviews was found to be in need of improvement.
作者： Sharea Ijaz , Jos H. Verbeek , Christina Mischke , Jani Ruotsalainen
DOI: 10.1016/J.JCLINEPI.2014.01.001
关键词: Alternative medicine 、 Comparative effectiveness research 、 Psychological intervention 、 Physical therapy 、 Pediatrics 、 Meta-analysis 、 Data extraction 、 Randomized controlled trial 、 Inclusion (education) 、 Medicine 、 Systematic review
摘要: Abstract Objectives Nonrandomized studies (NRSs) are considered to provide less reliable evidence for intervention effects. However, these included in Cochrane reviews, despite discouragement. There has been no evaluation of when and how designs used. Therefore, we conducted an overview current practice. Study Design Setting We all reviews that NRS, conducting inclusions data extraction duplicate. Results Of the 202 114 (56%) did not cite a reason including NRS. The reasons were divided into two major categories: NRS because randomized controlled trials (RCTs) wanted (N = 81, 92%) but feasible, lacking, or insufficient alone RCTs needed (N = 7, 8%). A range with before-after as most common. Most interventions nonpharmaceutical settings nonmedical. For risk bias assessment, Effective Practice Organisation Care Group's checklists used by reviewers (38%), whereas others variety self-constructed tools. Conclusion do justify When they do, line recommendations. Risk assessment varies across needs improvement.
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