Perfluoroalkanesulfonamide organocatalysts for asymmetric conjugate additions of branched aldehydes to vinyl sulfones.
作者： Kosuke Nakashima , Miho Murahashi , Hiroki Yuasa , Mariko Ina , Norihiro Tada
DOI: 10.3390/MOLECULES181214529
关键词: Organic chemistry 、 Adduct 、 Vinyl sulfone 、 Conjugate 、 Chemistry 、 Sulfonamide 、 Stereocenter
摘要: Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis the corresponding adducts with all-carbon quaternary stereocenters in excellent yields up 95% ee.
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