Formation and characterization of polyglutamate core-shell microspheres.

摘要: The need for organ-targeted delivery of drugs and imaging agents creates an interest in biocompatible, biodegradable vesicles. We make protein microspheres using high-intensity ultrasound; these have a shell hydrophobic interior, making them ideal delivering materials. previously shown that various proteins, e.g., bovine serum albumin (BSA), form microsphere stabilized by interprotein cross-linking cysteine residues. In this study, polyglutamate was used to core−shell at slightly basic pH sonication. These particles are smaller than our previous stable under conditions encountered vivo. stability appears be due hydrogen bonding networks not covalent cross-linking.