Molecular changes associated with the transmission of avian influenza a H5N1 and H9N2 viruses to humans.

摘要: In order to identify molecular changes associated with the transmission of avian influenza A H5N1 and H9N2 viruses humans, internal genes from these were compared sequences other human isolates. Phylogenetically, each all sixteen both isolates closely related one another fell into a distinct clade separate clades formed by same viruses. All six most those circulating in Asia, indicating that reassortment strains had not occurred for any 18 Amino acids previously identified as host-specific residues predominantly although proteins also contained observed only For majority nonglycoprotein genes, three subgroups could be distinguished on bootstrap analyses nucleotide sequences, suggesting multiple introductions virus capable infecting humans. The shared gene constellations their detection since 1997 when first infections detected suggest this particular combination may confer ability infect humans cause disease. J. Med. Virol. 66:107-114, 2002. Published 2002 Wiley-Liss, Inc.