Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
作者： Y. Yin , S.C. Le , A.L. Hsu , M.J. Borgnia , H. Yang
DOI: 10.2210/PDB6NR2/PDB
关键词: Membrane 、 Icilin 、 Chemistry 、 Allosteric regulation 、 Biophysics 、 Phosphatidylinositol 、 Ligand (biochemistry) 、 Menthol 、 TRPM8 、 Transient receptor potential channel
摘要: … thus far precluded a mechanistic understanding of ligand and lipid sensing by TRPM8. Using cryo–… amide bond, we anticipate that menthol binding to TRPM8 will be similar to that of the …
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