Exposure to Chemical Carcinogens During Pregnancy: Consequences for Mother and Conceptus

作者: Jerry M. Rice

DOI: 10.1007/978-1-4684-4811-5_2

关键词: Industrial exposureAsbestosChemical carcinogensObstetricsCancerCarcinogenPregnancyMedicinePhysiologyConceptusGestational choriocarcinoma

摘要: The causes of the overwhelming majority human neoplasms, including gestational choriocarcinoma, remain unknown. However, an increasing body evidence has shown that at least some cancers have resulted from exposure to non-infectious agents in environment. These include both ultraviolet and ionizing radiation, diverse cases as yet poorly characterized group organic inorganic substances industrial processes. International Agency for Research on Cancer recently concluded 7 such processes 23 chemicals groups are causally associated with certain humans (1). A few these listed Table 1; ironically, a significant number used clinically anti-neoplastic drugs. An additional 61 chemicals, or considered probably carcinogenic by Cancer. Hundreds more been cause tumors experimental animals, inference must be hazardous humans. While substances, minerals asbestos elements arsenic, chromium, their salts included this list, known cancer when applied experimentally animals caused either result consequence anti-tumor chemotherapy compounds low molecular weight, it is exclusively latter overview will concerned.

参考文章(68)
Fred J. Stevens, Carl Peraino, Liver as a Model System for Analyzing Mechanisms of Tumor Initiation and Promotion Organ and Species Specificity in Chemical Carcinogenesis. ,vol. 24, pp. 231- 252 ,(1983) , 10.1007/978-1-4684-4400-1_12
Sylvia D. Lawler, Genetic Studies on Hydatidiform Moles Human Trophoblast Neoplasms. ,vol. 176, pp. 147- 161 ,(1984) , 10.1007/978-1-4684-4811-5_8
Robert G. Croy, John M. Essigmann, Gerald N. Wogan, Aflatoxin B1: Correlations of Patterns of Metabolism and DNA Modification with Biological Effects Organ and Species Specificity in Chemical Carcinogenesis. ,vol. 24, pp. 49- 62 ,(1983) , 10.1007/978-1-4684-4400-1_3
Stuart H. Yuspa, Henry Hennings, Ulrike Lichti, Molly Kulesz-Martin, Organ Specificity and Tumor Promotion Organ and Species Specificity in Chemical Carcinogenesis. ,vol. 24, pp. 157- 171 ,(1983) , 10.1007/978-1-4684-4400-1_8
H. Druckrey, Ch. Landsch�tz, S. Ivankovic, [Transplacental induction of malignant tumours of the nervous system. II. Ethyl-nitrosurea in 10 genetically defined strains of rats]. Zeitschrift für Krebsforschung. ,vol. 73, pp. 371- 386 ,(1970) , 10.1007/BF00524174
Kurt Benirschke, Miguel Marin-Padilla, Thalidomide Induced Alterations in the Blastocyst and Placenta of the Armadillo, Dasypus novemcinctus mexicanus, Including a Choriocarcinoma American Journal of Pathology. ,vol. 43, pp. 999- 1016 ,(1963)
W. Wechsler, A. Koestner, J. A. Swenberg, Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats. American Journal of Pathology. ,vol. 63, pp. 37- 56 ,(1971)
Falk Hl, Jurgelski W, Hudson P, Tissue differentiation and susceptibility to embryonal tumor induction by ethylnitrosourea in the opossum. National Cancer Institute monograph. pp. 123- 158 ,(1979)
K.A.V.R. Krishnamachari, V. Nagarajan, RameshV. Bhat, T.B.G. Tilak, HEPATITIS DUE TO AFLATOXICOSIS: An Outbreak in Western India The Lancet. ,vol. 305, pp. 1061- 1063 ,(1975) , 10.1016/S0140-6736(75)91829-2