Lennox-Gastaut syndrome: (Childhood epileptic encephalopathy)

摘要: Lennox-Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by an electroclinical triad of generalized slow spike wave (SSW) activity in the EEG, multiple types seizures, and mental development. It usually subdivided into symptomatic cryptogenic types, latter accounting for at least one fourth all patients. Symptomatic cases are due to diverse cerebral conditions, which bilateral, diffuse, or multifocal, involving gray matter. Twenty percent patients with LGS have prior infantile spasms hypsarrythmia. The characteristic interictal EEG pattern 1.5 2.5 Hz SSW activity, bilaterally synchronous, dominant over frontocentral regions, symmetric. There varying degrees slowing background. Sleep discloses paroxysms fast (10 25 Hz) rhythmic activity.