Depression in Parkinson's disease: its prevalence, diagnosis, and neurochemical background.

摘要: There are several problems related to the diagnosis and biochemical background of depression in patients with Parkinson's disease (PD). The most important problem is how do we understand PD. According surveys using diagnostic procedures specified Diagnostic Statistic Manual-III or IV, prevalence 20–40 % However, reported rate varies according composition subject group whether not a control used, so it still controversial figure reflects actual depression. Latest studies showed about 2–8 PD diagnosed major by DSM-III-R. These recent suggest that may coexist dysthimic disorder be an essential feature With regard neurochemical background, level 5-hydroxyindoleacetic acid (a metabolite serotonin) reduced cerebrospinal fluid suggesting serotonergic dysfunction exists brain patients. there no high quality evidence indicate effectiveness selective serotonin reuptake inhibitors for Autopsy have revealed only serotonin, but also dopamine, noradrenaline other neurotransmitters brains Accordingly, treatment become difficult many cases due these changes multiple neurotransmitters. Development better strategy based on improved understanding needed.