Baicalein-phospholipid complex: a novel drug delivery technology for phytotherapeutics.
作者： Devendra Singh Rawat , Bandana K. Thakur , Mona Semalty , Ajay Semalty , Prabhakar Badoni
DOI: 10.2174/1570163811310030005
关键词: Dissolution 、 Solubility 、 Bioavailability 、 Intestinal absorption 、 Baicalein 、 Drug delivery 、 Absorption (skin) 、 Differential scanning calorimetry 、 Chemistry 、 Chromatography
摘要: Flavonoids are a group of low-molecular-weight polyphenolic compounds of plant origin. They exhibit a variety of biological activities such as anti-inflammatory, antioxidant, antiviral, and antitumor etc. Baicalein, is a bioactive flavone constituent of Scutellariae radix with a wide range of beneficial activities. But the poor solubility and dissolution rate limit its oral intestinal absorption and bioavailability. The aim of this study was to develop an amphiphilic phytophospholipid complex in order to enhance the delivery of poorly soluble drug …
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researchgate.net 参考文章(36)
Y Javadzadeh, M Barzegar-Jalali, A Nokhodchi, Siahi-Shadbad, The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences. ,vol. 8, pp. 18- 25 ,(2005)
Andrea Giori, Federico Franceschi, Phospholipid complexes of olive fruits or leaves extracts having improved bioavailability ,(2007)
M. Perrut, J. Jung, F. Leboeuf, Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes. Part I: Micronization of neat particles. International Journal of Pharmaceutics. ,vol. 288, pp. 3- 10 ,(2005) , 10.1016/J.IJPHARM.2004.09.007
P. A. Illich, E. J. Dial, J. J. Romero, C. Ulloa, A. L. Vanous, Edgar T Walters, Lenard M Lichtenberger, Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems. Journal of Pharmacology and Experimental Therapeutics. ,vol. 277, pp. 1221- 1227 ,(1996)
Lenard M. Lichtenberger, Zu-Mo Wang, Jimmy J. Romero, Carlos Ulloa, Joseph C. Perez, Marie-Noëlle Giraud, José C. Barreto, Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury Nature Medicine. ,vol. 1, pp. 154- 158 ,(1995) , 10.1038/NM0295-154
I. Erlund, T. Kosonen, G. Alfthan, J. Mäenpää, K. Perttunen, J. Kenraali, J. Parantainen, A. Aro, Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. European Journal of Clinical Pharmacology. ,vol. 56, pp. 545- 553 ,(2000) , 10.1007/S002280000197
Ajay Semalty, Mona Semalty, Mohan Singh Maniyari Rawat, Federico Franceschi, Supramolecular phospholipids-polyphenolics interactions: the PHYTOSOME strategy to improve the bioavailability of phytochemicals. Fitoterapia. ,vol. 81, pp. 306- 314 ,(2010) , 10.1016/J.FITOTE.2009.11.001
T Van Nijlen, K Brennan, G Van den Mooter, N Blaton, R Kinget, P Augustijns, Improvement of the dissolution rate of artemisinin by means of supercritical fluid technology and solid dispersions. International Journal of Pharmaceutics. ,vol. 254, pp. 173- 181 ,(2003) , 10.1016/S0378-5173(03)00009-7
Yu Huang, Chi Ming Wong, Chi-Wai Lau, Xiaoqiang Yao, Suk Ying Tsang, Ya Lun Su, Zhen Yu Chen, Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings Biochemical Pharmacology. ,vol. 67, pp. 787- 794 ,(2004) , 10.1016/J.BCP.2003.10.002
M. Moneghini, I. Kikic, D. Voinovich, B. Perissutti, J. Filipović-Grčić, Processing of carbamazepine-PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution. International Journal of Pharmaceutics. ,vol. 222, pp. 129- 138 ,(2001) , 10.1016/S0378-5173(01)00711-6