Safety of ciprofloxacin in children: Worldwide clinical experience based on compassionate use. Emphasis on joint evaluation

摘要: Six hundred and thirty four adolescents children aged three days to 17 years treated with ciprofloxacin on a compassionate basis were analysed for drug safety. 62% of the courses given patients respiratory tract infection, primarily those acute pulmonary exacerbation cystic fibrosis. The mean daily oral dose was 25.2 mg/kg body weight. duration treatment ranged from one 880 (mean 22.8 days). Because arthropathogenic potential quinolones in juvenile animals special emphasis placed evaluation musculoskeletal adverse events. Arthralgia considered by treating physicians be related reported eight children, all whom females. resolved children. Some these subsequent no complaints arthralgia. Overall, safety profile is not substantially different that adults.