Treatment of Chronic Hepatitis B in Children

摘要: Awareness of the natural history chronic hepatitis B infection in children is central to any decisions regarding treatment. A child with HBV should have serological markers (HBsAg, HBeAg, and/or DNA) on two occasions at least 6 months apart be considered for liver biopsy may helpful before starting treatment. Therapeutic goals include long-term suppression replication, cessation injury, and reduction risk cirrhosis hepatocellular carcinoma. Currently, six agents classes (interferons nucleot(s)ide analogs) are available treatment but only interferon-alfa lamivudine licensed USA less than 12 years age. There limited information use other analogs children, although studies ongoing. Co-infections C or human immunodeficiency virus require special approaches infection. Given concerns about history, therapeutic options, serious resistance antiviral agents, an optimal regimen has not yet been developed, clinicians these prudently.