Immunologic assessment of regional lymph node histology in relation to survival in head and neck carcinoma.

作者: N. T. Berlinger , V. Tsakraklides , K. Pollak , G. L. Adams , M. Yang

DOI: 10.1002/1097-0142(197602)37:2<697::AID-CNCR2820370214>3.0.CO;2-I

关键词: Lymph nodeGerminal centerLymphMedicineDouble blindStage (cooking)Head and neck carcinomaHistologyPathologyIn patient

摘要: Histologic material from 84 cases of squamous cell carcinoma head and neck regions was studied by double blind retrospective analysis. Sections lymph nodes draining the tumors were examined microscopically to assess morphologic pattern response. Patients whose demonstrated active immunologic responses in form expanded inner cortices or increased numbers germinal centers had 5-year survival rates significantly greater than those patients regional showed an unstimulated pattern. None depleted survived 5 years. These correlations independent stage grade tumor. Metastases occurred much more frequently having showing evidence activity. The data support concept a relationship between activity, progression neoplasia, survival. Morphologic assessment activity malignant appear be significant value predicting

参考文章(20)
C. M. Pinsky, A. El Domeiri, A. S. Caron, W. H. Knapper, H. F. Oettgen, Delayed-Hypersensitivity Reactions in Patients with Cancer Springer, Berlin, Heidelberg. pp. 37- 41 ,(1974) , 10.1007/978-3-642-49284-6_6
KARL ERIK HELLSTRÖM, INGEGERD HELLSTRÖM, The Role of Cell-Mediated Immunity in Control and Growth of Tumors Clinical Immunobiology. ,vol. 2, pp. 233- 264 ,(1974) , 10.1016/B978-0-12-070002-8.50014-X
Tsakraklides E, Tsakraklides, Good Ra, An autopsy study of human axillary lymph node histology. American Journal of Pathology. ,vol. 78, pp. 7- 22 ,(1975)
Bernard Straus, Magdalena R. Berenyi, Ji-Ming Huang, Eugene Straus, Delayed hypersensitivity in alcoholic cirrhosis. Digestive Diseases and Sciences. ,vol. 16, pp. 509- 516 ,(1971) , 10.1007/BF02235541
W B Wartman, Sinus Cell Hyperplasia of Lymph Nodes Regional to Adenocarcinoma of the Breast and Colon British Journal of Cancer. ,vol. 13, pp. 389- 397 ,(1959) , 10.1038/BJC.1959.44
Stephen H. Bennett, James W. Futrell, Joel A. Roth, Robert C. Hoye, Alfred S. Ketcham, Prognostic significance of histologic host response in cancer of the larynx or hypopharynx. Cancer. ,vol. 28, pp. 1255- 1265 ,(1971) , 10.1002/1097-0142(1971)28:5<1255::AID-CNCR2820280524>3.0.CO;2-A