Seroprevalence of Various Infectious Agents in Dogs with Suspected Acute Canine Polyradiculoneuritis

摘要: Background: Acute canine polyradiculoneuritis (ACP) is considered to be an animal model of the acute axonal form Guillain-Barre syndrome (GBS) in humans. Various antecedent events have been associated with GBS, including bacterial or viral infection. The relationship between ACP and previous infection requires additional attention. Hypothesis: We hypothesized a serological evidence exposure Ehrlichia canis, Borrelia burgdorferi, Toxoplasma gondii, Neospora caninum, Campylobacter jejuni, distemper virus (CDV). Animals: Eighty-eight client-owned dogs, 44 ACP, age-matched controls. Methods: Retrospective study stored serum samples. Serum antibodies against target organisms were measured commercially available assays. Sera from dogs without that positive for T. gondii IgG by ELISA assayed heavy chain-specific, Western blot immunoassay. Results: Dogs (55.8%) more likely antibody titers than (11.4%). 8 affected 11 control bound antigens apparent molecular masses 67, 61, 58, 45, 33, 24, 9, 6 kDa. An antigen mass 36 kDa was recognized 2 but none dogs. Conclusions: Results this suggest some like GBS humans, may triggered prospective should performed further evaluate potential association.