A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin.
作者： Mette M.H. Christensen , Rasmus S. Pedersen , Tore B. Stage , Charlotte Brasch-Andersen , Flemming Nielsen
DOI: 10.1097/FPC.0B013E328364A57D
关键词: Kidney metabolism 、 Linkage disequilibrium 、 Gene 、 Gene interaction 、 Genetic variation 、 Metformin 、 SNP 、 Medicine 、 Genotype 、 Internal medicine 、 Endocrinology
摘要: ObjectiveThe aim of this study was to determine the association between renal clearance (CLrenal) metformin in healthy Caucasian volunteers and single-nucleotide polymorphism (SNP) c.808G>T (rs316019) OCT2 as well relevance gene–gene interactions SNP (a)
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