Aldehyde-induced protein modifications in human plasma: Protection by glutathione and dihydrolipoic acid

摘要: Exposure of human plasma to gas phase cigarette smoke (CS) produces a depletion ascorbic acid, peroxidation lipids (Frei et al. Biochem J 1991; 277: 133-8), and protein modification (as measured by carbonyl accumulation loss sulfhydryl groups) (Reznick 1992; 286: 607-11). CS contains both saturated unsaturated aldehydes. The contribution these aldehydes the damaging effects on was investigated. Aldehydes present in did not cause antioxidants such as acid or alpha-tocopherol induce lipid peroxidation. decreased concentrations but increased carbonyls. thiols glutathione dihydrolipoic had significant effect reducing aldehyde-induced modifications.