Oligopeptide complex for targeted non-viral gene delivery to adipocytes
作者： Young-Wook Won , Partho Protim Adhikary , Kwang Suk Lim , Hyung Jin Kim , Jang Kyoung Kim
DOI: 10.1038/NMAT4092
关键词: Adipokine 、 Adipose tissue 、 Oligopeptide 、 Molecular biology 、 Adipocyte 、 Prohibitin 、 Chemistry 、 Transfection 、 Small hairpin RNA 、 Inflammation
摘要: An adipocyte-targeting gene-carrier complex is shown to selectively transfect mature adipocytes by binding the protein prohibitin and lead metabolic recovery more than 20% body-weight reduction in obese mice.
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