Emerging roles of SIRT6 in human diseases and its modulators.

作者: Gang Liu , Haiying Chen , Hua Liu , Wenbo Zhang , Jia Zhou

DOI: 10.1002/MED.21753

关键词: ArthritisInflammationSteatohepatitisDNA repairSirtuinMedicineCancerSignal transductionSIRT6Bioinformatics

摘要: … The yeast silent information regulator two (Sir2), a NAD + -… Observations in the functions of controlling DNA damage repair… was found to be reversed by runt-related transcription factor 2 (…

参考文章(329)
Giovanna Sociali, Lauretta Galeno, Marco Daniele Parenti, Alessia Grozio, Inga Bauer, Mario Passalacqua, Silvia Boero, Alessandra Donadini, Enrico Millo, Marta Bellotti, Laura Sturla, Patrizia Damonte, Alessandra Puddu, Claudia Ferroni, Greta Varchi, Claudio Franceschi, Alberto Ballestrero, Alessandro Poggi, Santina Bruzzone, Alessio Nencioni, Alberto Del Rio, Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. European Journal of Medicinal Chemistry. ,vol. 102, pp. 530- 539 ,(2015) , 10.1016/J.EJMECH.2015.08.024
Selma Masri, Sirtuin-dependent clock control Current Opinion in Clinical Nutrition and Metabolic Care. ,vol. 18, pp. 521- 527 ,(2015) , 10.1097/MCO.0000000000000219
Maierhaba Ailixiding, Zulipiya Aibibula, Munetaka Iwata, Jinying Piao, Yasushi Hara, Daisuke Koga, Atsushi Okawa, Sadao Morita, Yoshinori Asou, Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis. Biochemical and Biophysical Research Communications. ,vol. 466, pp. 319- 326 ,(2015) , 10.1016/J.BBRC.2015.09.019
Ronald A. McCord, Eriko Michishita, Tao Hong, Elisabeth Berber, Lisa D. Boxer, Rika Kusumoto, Shenheng Guan, Xiaobing Shi, Or Gozani, Alma L. Burlingame, Vilhelm A. Bohr, Katrin F. Chua, SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair Aging-us. ,vol. 1, pp. 109- 121 ,(2009) , 10.18632/AGING.100011
Hwa-Suk Lee, Sun-O Ka, Sang-Myeong Lee, Sang-Il Lee, Jin-Woo Park, Byung-Hyun Park, Overexpression of Sirtuin 6 Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen‐Induced Arthritis Arthritis & Rheumatism. ,vol. 65, pp. 1776- 1785 ,(2013) , 10.1002/ART.37963
Shan-Shan Yu, Yi Cai, Jian-Tao Ye, Rong-Biao Pi, Shao-Rui Chen, Pei-Qing Liu, Xiao-Yan Shen, Yong Ji, Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF‐κB‐dependent transcriptional activity British Journal of Pharmacology. ,vol. 168, pp. 117- 128 ,(2013) , 10.1111/J.1476-5381.2012.01903.X
Cris S Constantinescu, Nasr Farooqi, Kate O'Brien, Bruno Gran, Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) British Journal of Pharmacology. ,vol. 164, pp. 1079- 1106 ,(2011) , 10.1111/J.1476-5381.2011.01302.X
Xiwen Xiong, Gaihong Wang, Rongya Tao, Pengfei Wu, Tatsuyoshi Kono, Kevin Li, Wen-Xing Ding, Xin Tong, Sarah A. Tersey, Robert A. Harris, Raghavendra G. Mirmira, Carmella Evans-Molina, X. Charlie Dong, Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells Diabetologia. ,vol. 59, pp. 151- 160 ,(2016) , 10.1007/S00125-015-3778-2
Stephan Winnik, Johan Auwerx, David A. Sinclair, Christian M. Matter, Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. European Heart Journal. ,vol. 36, pp. 3404- 3412 ,(2015) , 10.1093/EURHEARTJ/EHV290