Anaemia in haemodialysis patients of five European countries: association with morbidity and mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

摘要: BACKGROUND The Dialysis Outcomes and Practice Patterns Study (DOPPS) is a prospective, observational study based on data collected from nationally representative samples of haemodialysis facilities. burden anaemia in patients substantial, leading to considerable morbidity, mortality reduced quality life. This examines management outcomes five European countries participating the DOPPS: France, Germany, Italy, Spain UK. METHODS Baseline demographics, co-morbidities 4591 101 nephrology facilities were 1998-2000. Using multivariate Cox survival analyses adjust for patient characteristics, relationships between haemoglobin concentration at entry rates hospitalization evaluated. RESULTS For year 2000 sample prevalent >180 days, mean was 11.0 g/dl; 53% had > or = 11 g/dl [1998-1999 44% (P < 0.05)]. In 2000, 84% prescribed recombinant human erythropoietin (rHuEpo). Higher concentrations associated with decreased relative risk (RR) (RR 0.95 every 1 higher haemoglobin, P 0.03) 0.96, 0.02). Patients <10 29% more likely be hospitalized than 11-12 0.001). CONCLUSION Even after adjustment, lower morbidity patients. A trend increased observed following publication Best Guidelines (EBPG) chronic kidney disease patients, but efforts must continue achieve EBPG goals.