Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR‐623, a Novel Liver X‐Receptor Agonist, in Healthy Participants

作者: Arie Katz , Chandrasekhar Udata , Elyssa Ott , Lisa Hickey , Michael E. Burczynski

DOI: 10.1177/0091270009335768

关键词: Liver X receptorBiologyPharmacokineticsPopulationABCA1AgonistReverse cholesterol transportCholesterolPharmacodynamicsPharmacology

摘要: … In this study, we administered either LXR-623, a novel LXR α and β agonist, or placebo to … LXR-623 was absorbed relatively rapidly following oral administration. LXR-623 plasma …

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