Clinical Outcomes in Elderly Patients with Metastatic Colorectal Cancer Receiving Bevacizumab and Chemotherapy: Results from the BRiTE Observational Cohort Study

作者: Mark F. Kozloff , Jordan Berlin , Patrick J. Flynn , Fairooz Kabbinavar , Mark Ashby

DOI: 10.1159/000320222

关键词: BevacizumabMetastasisSurvival analysisSurgeryInternal medicineClinical trialColorectal cancerProportional hazards modelMedicineCancerCohort study

摘要: Background: Elderly patients are underrepresented in clinical trials and frequently undertreated with standard therapy. The BRiTE observational cohort study assessed the safety

参考文章(17)
Timothy L. Gillison, Gurkamal S. Chatta, Cancer Chemotherapy in the Elderly Patient Oncology. ,vol. 24, pp. 76- 85 ,(2010)
Fairooz Kabbinavar, Herbert I. Hurwitz, Louis Fehrenbacher, Neal J. Meropol, William F. Novotny, Grazyna Lieberman, Susan Griffing, Emily Bergsland, Phase II, Randomized Trial Comparing Bevacizumab Plus Fluorouracil (FU)/Leucovorin (LV) With FU/LV Alone in Patients With Metastatic Colorectal Cancer Journal of Clinical Oncology. ,vol. 21, pp. 60- 65 ,(2003) , 10.1200/JCO.2003.10.066
Xu Zhang, Fausto R. Loberiza, John P. Klein, Mei-Jie Zhang, A SAS macro for estimation of direct adjusted survival curves based on a stratified Cox regression model Computer Methods and Programs in Biomedicine. ,vol. 88, pp. 95- 101 ,(2007) , 10.1016/J.CMPB.2007.07.010
Napoleone Ferrara, Hans-Peter Gerber, None, The Role of Vascular Endothelial Growth Factor in Angiogenesis Acta Haematologica. ,vol. 106, pp. 148- 156 ,(2001) , 10.1159/000046610
Xu Zhang, Fausto R. Loberiza, John P. Klein, Mei-Jie Zhang, Erratum to “A SAS macro for estimation of direct adjusted survival curves based on a stratified Cox regression model” [Comput. Meth. Prog. Biomed. 88 (2007) 95–101] Computer Methods and Programs in Biomedicine. ,vol. 89, pp. 313- 314 ,(2008) , 10.1016/J.CMPB.2007.11.003
Edward L. Trimble, Michaele C. Christian, Cancer Treatment and the Older Patient Clinical Cancer Research. ,vol. 12, pp. 1956- 1957 ,(2006) , 10.1158/1078-0432.CCR-06-0364
Fairooz F. Kabbinavar, Herbert I. Hurwitz, Jing Yi, Somnath Sarkar, Oliver Rosen, Addition of Bevacizumab to Fluorouracil-Based First-Line Treatment of Metastatic Colorectal Cancer: Pooled Analysis of Cohorts of Older Patients From Two Randomized Clinical Trials Journal of Clinical Oncology. ,vol. 27, pp. 199- 205 ,(2009) , 10.1200/JCO.2008.17.7931
Axel Grothey, Mary M. Sugrue, David M. Purdie, Wei Dong, Daniel Sargent, Eric Hedrick, Mark Kozloff, Bevacizumab Beyond First Progression Is Associated With Prolonged Overall Survival in Metastatic Colorectal Cancer: Results From a Large Observational Cohort Study (BRiTE) Journal of Clinical Oncology. ,vol. 26, pp. 5326- 5334 ,(2008) , 10.1200/JCO.2008.16.3212
James Cassidy, Leonard B. Saltz, Bruce J. Giantonio, Fairooz F. Kabbinavar, Herbert I. Hurwitz, Ulrich-Peter Rohr, Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies. Journal of Cancer Research and Clinical Oncology. ,vol. 136, pp. 737- 743 ,(2010) , 10.1007/S00432-009-0712-3
F. A. Scappaticci, J. R. Skillings, S. N. Holden, H.-P. Gerber, K. Miller, F. Kabbinavar, E. Bergsland, J. Ngai, E. Holmgren, J. Wang, H. Hurwitz, Arterial Thromboembolic Events in Patients with Metastatic Carcinoma Treated with Chemotherapy and Bevacizumab Journal of the National Cancer Institute. ,vol. 99, pp. 1232- 1239 ,(2007) , 10.1093/JNCI/DJM086