Alcohol and HER2 polymorphisms as risk factor for cardiotoxicity in breast cancer treated with trastuzumab.
作者： Corinne Nadeau-Larochelle , Rosemarie Tremblay-Lemay , Caroline Diorio , Frédéric Barabé , Marc-André Côté
DOI:
关键词: Retrospective cohort study 、 Genotype 、 Medicine 、 Internal medicine 、 Trastuzumab 、 Medical record 、 Risk factor 、 Alcohol 、 Breast cancer 、 Cardiotoxicity 、 Oncology
摘要: BACKGROUND Trastuzumab has no major side-effects except the potential for cardiac toxicity. The main objective of this study was to evaluate association between trastuzumab-associated toxicity and two risk factors: alcohol intake HER2 polymorphisms. PATIENTS AND METHODS In a retrospective cohort 237 women with non-metastatic HER2-positive breast cancer treated trastuzumab, traditional factors were assessed by review medical records, use an administered questionnaire (n=132), polymorphisms (Ile655Val Ala1170Pro) using TaqMan assays (n=73). RESULTS Association observed (10 drinks more per week) during trastuzumab treatment (p=0.04). For polymorphisms, compared Ile/Ile carriers, Ile/Val associated higher (p=0.02). CONCLUSION Heavy course genotype may constitute
参考文章(0)