Haemodynamic and metabolic changes induced by repeated episodes of hypoxia in pigs

摘要: Background: Repeated hypoxia and surgical trauma trigger a potent neuroendocrine response their association is thought to play pivotal role in the pathogenesis of multi-organ dysfunction. We investigated cardiovascular metabolic responses repeated acute anaesthetised surgically instrumented pigs. Methods: Under ketamine-midazolam anaesthesia, 15 pigs were for measurements cardiac output, vascular pressures organ blood flows. Lactate production O2 uptake determined brain, liver, kidney intestine. Ten animals subjected two 12-min periods ventilatory (FIO2=7%) followed by re-oxygenation 5 underwent 120–min normoxic ventilation (Control group). Results: Both hypoxic challenges produced comparable release catecholamines that was associated with increased output redistribution flow away from intestinal renal areas towards brain liver; markedly reduced intestine (– 56 ± 10%, P < 0.05) least affected 19±12% — 23±21%, respectively). During second test, lethal depression occurred animals; these non-survivors demonstrated impaired hyperdynamic incomplete recovery during first hypoxia/reoxygenation test. In Control group, not significant haemodynamic changes. Conclusion: Intraoperative causes marked heterogeneity metabolism. The inability develop event, as well persistent debt following re-oxygenation, predict occurrence death insult.