Biological Characteristics and Long-term Outcomes in Node-negative Breast Cancer.
作者： Elisa Agostinetto , Laura Giordano , Rosalba Torrisi , Rita De Sanctis , Giovanna Masci
DOI: 10.1016/J.CLBC.2020.02.011
关键词: Oncology 、 Multivariate analysis 、 Univariate analysis 、 Long term outcomes 、 Node negative 、 Proliferation index 、 Medicine 、 Internal medicine 、 Relapse risk 、 Breast cancer 、 Disease
摘要: Abstract Background Since the risk of relapse node-negative breast cancer (BC) is varying, we evaluated prognosis patients with this disease and factors associated increased relapse. Methods The clinical charts BC evidence negative nodes a potential ≥5-year follow-up were retrospectively reviewed. Results We analyzed 1276 patients. Over median 71.6 months (range: 1–227.2 months), observed 159 events or death. Median RFS was 170 months. OS 192 At univariate analysis, older age, hormonal receptors, larger tumor size higher proliferation index (Ki67) worse (p multivariate analysis for RFS, Ki67 confirmed their independent prognostic role. OS, age positive receptors showed an no differences in between HER2-positive TNBC, but TNBC compared luminal-like BC. Conclusions In BC, receptor status, factors. subtype not poorer subtype,
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