Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma

摘要: Mixed hepatocellular cholangiocarcinoma (HCC-CC) and intrahepatic (I-CC) are increasingly being reported in patients with cirrhosis. The aims of this study were (1) to evaluate the incidence, imaging features, posttransplant outcomes for who underwent transplantation carcinoma (HCC) found have HCC-CC or I-CC explant (2) compare these those controls HCC matched (1:3) by tumor size number nodules explant. In specimens 10 302 (3.3%) liver (LT) HCC, mixed was identified. There 4 additional incidental cases HCC-CC. After a median follow-up period 32 months, 8 14 (57%) suffered from recurrence, disease-free survival time months. cumulative risk recurrence 40% 70% at 1 5 years, respectively, patients. When excluded, group (n = 10) had significantly lower incidence well-differentiated tumors (11.1% versus 43.3%, P < 0.02) higher rate (60% 16.7%, 0.008) comparison control 30). 1- 5-year risks 42% 65%, 10% 17%, (P 0.002). actuarial patient rates without also (79% 32% 90% 62% group, 0.03). Dynamic contrast-enhanced computed tomography magnetic resonance showed progressive contrast enhancement throughout arterial portal venous phases washout conclusion, associated poor prognosis high after LT, both exhibit radiographic features that distinct observed HCC.