Hydrogen peroxide cytotoxicity under conditions of normal or reduced catalase activity in H2O2-sensitive and -resistant Chinese hamster ovary (CHO) cell variants.

摘要: H2O2-sensitive and -resistant sublines of Chinese Hamster Ovary (CHO) cells were tested for their sensitivity to the growth inhibitory effect elicited by increasing concentrations oxidant under conditions normal or reduced catalase activity. Experimental results have demonstrated that, activity, cytotoxic action H2O2 was differentially regulated in resistant sensitive cells. Indeed, parental cell line low (V 250 cells) depended on a lower extent than did highly 850 cells). It is interesting note that V had more catalase, per million basis, We conclude acquired resistance oxidative stress not entirely dependent contribution depends degree oxidant.