Adverse Reactions to Selective Cyclooxygenase-2 Inhibitors (Coxibs)

摘要: Coxibs, selective inhibitors of arachidonic acid cyclooxygenase-2, constitute a new, clinically useful therapeutic class drugs that possess analgesic, antiinflammatory, and antipyretic properties. The drug inserts prescription information presently provide warning contraindicating their use in patients with aspirin-intolerant asthma aspirin NSAID hypersensitivity. However, according to investigations reported until now, most those NSAID-sensitive individuals will tolerate coxibs. Careful oral challenge is for patient management since some cutaneous systemic reactions hypersensitivity, especially when sulfonamide-containing coxibs are employed, may occur.