ER-to-Golgi Transport: The COPII-Pathway

摘要: The endoplasmic reticulum (ER) is the starting site of journey newly synthesized proteinsto apoplast, plasma membrane and to vacuolar compartments. Transport between these membranecompartments secretory pathway in eukaryotic cells mediated by vesicles, which are producedby a budding mechanism involving coat proteins that capture specific cargo molecules helppackage them into coated vesicles. These vesicles known as COPII-coated usuallyisolated after their induction vitro using microsomal membranes, cytosol non-hydrolyzableGTP-analogue. formed at sites ER ER-exit sites(ERES). ERES well-characterized mammalian cells, can be recognized some algae, but controversysurrounds identification higher plant cells.