Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives

摘要: Hemophilia is a bleeding disorder that afflicts about 1 in 5000 males. Treatment relies upon replacement of the deficient factor, and response to treatment both clinical research practice based subjective parameters such as pain joint mobility. Existing laboratory assays quantify amount factor plasma, which useful diagnostically prognostically. However, these are limited their ability fully evaluate patient’s clot-forming capability. Newer assays, known global provide far more detailed view thrombin generation clot formation have been studied hemophilia for 10 years. They potential offer objective measure hemophilic phenotype well treatment. In particular, patients who develop inhibitors clotting factors whom bypassing agents required hemostasis, opportunity determine interventions where traditional coagulation cannot. this article we review existing literature discuss several controversial issues surrounding assays. Last, vision future uses briefly described.