The Diathesis–Epilepsy Model: How Past Events Impact the Development of Epilepsy and Comorbidities

摘要: In epilepsy, seizures and comorbidities (e.g., cognitive deficits depression) occur when specific thresholds are crossed. These depend on the diathesis (or vulnerability) of a given individual. The is controlled by multiple genetic environmental factors. Diathesis changes over timescales: daily basis, as part development/aging processes, etc. diathesis-epilepsy model introduced here provides conceptual framework to understand how past events very stressful event) can directly influence occurrence epilepsy later in life. Experimental evidence supports this model, existence biomarkers predictive vulnerability state have led development preventive therapeutic strategies. Epigenetic modifications could be key determinant diathesis. Their role discussed.