Novel formulations of proton pump inhibitors and methods of using these formulations
作者： Kay Olmstead , Laura Weston , Craig Bowe , Laura Gallo , Warren Hall
DOI:
关键词: Pharmacodynamics 、 Chemical stability 、 Gastrointestinal disorder 、 Bioavailability 、 Pharmacology 、 Chemistry 、 Buffering agent 、 Physical stability 、 Combinatorial chemistry 、 Pharmacokinetics
摘要: The present invention relates to combinations of a proton pump inhibiting agent and at least one buffering that have been found possess improved bioavailability, chemical stability, physical dissolution profiles, disintegration times, as well other pharmacokinetic, pharmacodynamic, and/or properties. is directed methods, kits, combinations, compositions for treating, preventing or reducing the risk developing gastrointestinal disorder disease including nocturnal acid breakthrough, symptoms associated therewith
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