New laboratory tools in the assessment of bone quality

摘要: Bone quality is a complex set of intricated and interdependent factors that influence bone strength. A number methods have emerged to measure quality, taking into account the organic or mineral phase matrix, in laboratory. different are interdependent. The matrix organization can be described at five levels anatomical organization: nature (organic mineral), texture (woven lamellar), structure (osteons cortices arch-like packets trabecular bone), microarchitecture, macroarchitecture. Any change one these alter quality. An altered remodeling affect by influencing more factors. We reviewed here main used laboratory explore on samples. evaluated histomorphometry; microarchitecture explored 2D histological sections 3D microCT synchrotron. Microradiography scanning electron microscopy backscattered mode distribution; Raman Fourier-transformed infra-red spectroscopy imaging simultaneously multispectral images; acoustic nanoindentation provide biomechanical information individual trabeculae. Finally, some (polarization, surface staining, fluorescence, osteocyte staining) may also interest understanding as component fragility. growing techniques now available. Some them been many years ago find new youth; others having benefited from improvements physical computer