Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity.
作者： Takashi Nakamura , Koharu Yamada , Yusuke Sato , Hideyoshi Harashima
DOI: 10.1016/J.IJPHARM.2020.119652
关键词: Lipid bilayer fusion 、 Transfection 、 Cell biology 、 Cell therapy 、 Immune system 、 Chemistry 、 Cell culture 、 Cell membrane 、 Jurkat cells 、 Cell
摘要: … Based on the CLSM images (Fig. 5B), we hypothesized that membrane fusion occurred … Our results indicate that membrane fusion was induced between the YSK12-MEND and the …
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