作者: WilliamE. Evans , JosephA. Sinkule , WilliamR. Crom , Lois Dow , A.Thomas Look
DOI: 10.1007/BF00254537
关键词: Urine 、 Etoposide 、 Leukemia 、 Acute leukemia 、 Teniposide 、 Pharmacology 、 Cancer 、 Distribution (pharmacology) 、 Chemistry 、 Pharmacokinetics
摘要: The clinical pharmacokinetics of VM26 and VP16-213 were assessed in 15 children (median age 10 years) with acute leukemia, using a new high-performance liquid chromatography—electrochemical assay. Pharmacokinetic parameters calculated by both model-dependent compartment model-independent methods. These studies demonstrated substantial differences the central volumes distribution (VDc), steady-state (VDss) systemic clearances (Cls) VP16-213; VDc, VDss, Cls all being smaller for VM26. Systemic determined methods 5.2±1.0 ml/min/m2 (mean±SD) 17.8±11.2 VP16-213. major metabolites detected serum urine hydroxy acids. Low levels picro-lactone isomers some patients while aglycones not or any patients.