THE TRANSPORT OF SUGARS INTO THE LENS.

摘要: Evidence has been presented supporting the concept of a mediated transfer certain sugars into calf and rat lenses. This conclusion was reached from observation structural requirements for entry closely related lens, kinetic analysis lens. At high sugar concentrations, saturation binding sites competition between pairs monosaccharides were demonstrable in Galactose appeared to have potentiality penetrating cells lens by simple diffusion or utilizing sites. Glucose fructose competed utilization with former appearing five six times affinity latter. A number carbohydrates apparently pass through capsule but are unable cross cellular membranes. E, Ifforts evaluate uptake stimulated occurrence diabetic other forms cataract, recent demonstration sorbitol pathway. However, interest focused on metabolism these substances, only last few years reports emphasizing transport this tissue. 1 " 3 Although processes controlling movement across lenticular membranes obvious importance, very little is known concerning them. Detailed investigations made tissues such as kidney intestine, both which accumulate 4 ; "mediated transfer" demonstrated muscle, erythrocytes, placenta, tumor cells. 5 The term, "me