Chapter 15 Systemic Lupus Erythematosus and Endocrine Disorders

作者: Sara Cortes , Ana Jerónimo , David Isenberg

DOI: 10.1016/S1571-5078(07)00215-2

关键词: Endocrine systemThyroid diseaseImmunologyThyroidAnti-SSA/Ro autoantibodiesSystemic inflammationHormoneThyroiditisMedicineSystemic lupus erythematosus

摘要: Publisher Summary This chapter discusses the systemic lupus erythematosus (SLE) and endocrine disorders. In patients with SLE disease activity, it is clearly influenced by hormonal variations that are linked to gender, aging, changes in reproductive status. Substantial progress has been made clarifying signaling molecules receptors involved these processes understanding immunomodulatory effects of numerous mediators, such as estrogen or cortisol. The overlap thyroid frequently described, but there relatively less information available regarding association other reason for higher prevalence antithyroid antibodies remains poorly understood, perhaps represents silent thyroiditis associated inflammation. These disorders may precede development signs years develop many afterward this should be considered clinical evaluation their complaints.

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