Role of Tat Protein in HIV Neuropathogenesis
作者： Wenxue Li , Guanhan Li , Joseph Steiner , Avindra Nath
DOI: 10.1007/S12640-009-9047-8
关键词: Gene 、 Virus 、 Regulatory sequence 、 Chemokine 、 Cell 、 Neuropathogenesis 、 Immunology 、 Biology 、 Regulation of gene expression 、 Cell surface receptor 、 Virology
摘要: The Tat protein of the human immunodeficiency virus (HIV) has been implicated in pathophysiology neurocognitive deficits associated with HIV infection. This is earliest to be produced by proviral DNA infected cell. not only drives regulatory regions but may also actively released from cell and then interact surface receptors other uninfected cells brain leading cellular dysfunction. It taken up these can activate a number host genes. highly potent unique ability travel along neuronal pathways. Importantly, its production impacted use antiretroviral drugs once formed. article reviews pleomorphic actions evidence supporting central role neuropathogenesis
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