Hydro-Ethanolic Extract of Mentha pulegium Exhibit Anthelmintic and Antioxidant Proprieties In Vitro and In Vivo.

摘要: During recent decades, the emergence of chemoresistance among synthetic anthelmintic drugs has increased interest in screening novel natural compounds derived from plants. The current study is aimed to determine chemical profile, and antioxidant properties Mentha pulegium hydro-ethanolic extract. Two tests were used assess vitro activity extract M. against Haemonchus contortus; egg hatch assay (EHA) adult worm motility (AWM) assay. extracts at doses 500, 1000, 2000 4000 mg/kg evaluated vivo mice infected with Heligmosomoides polygyrus. efficacy was monitored using faecal count reduction (FECR) total (TWCR). by testing capacity DPPH free radical-scavenging ability. Chromatographic characterization composition RP-HPLC revealed presence phenolic acids such as syringic acid, ferulic acid flavonoid compounds, isorhamnetin-3-O-glucoside kaempferol-3-O-rutinoside. We observed 91.58% inhibition EHA 8 mg/mL after 48 h incubation (IC50=1.82 mg/mL). In AWM assay, achieved 65.2% h. highest dose (4000 mg/kg) showed a significant nematicidal effect 7 days post-treatment inducing 60.39% FECR 71.6% TWCR. also report strong extract, increase enzymatic activities catalase (CAT), superoxide dismutase (SOD) glutathione peroxidase (GPx) enzymes H. Together, results this paper suggest that possesses could be potential source for control helminth parasites well its associated oxidative damage.