Smoothelins and the Control of Muscle Contractility.

摘要: Smooth muscle cells display distinctive expression and organization of contractile filament proteins, which reflect a unique method regulation. As the focus this review, smoothelin smoothelin-like family members represent poorly understood proteins that appear to act as structural components apparatus. The protein is characterized by presence single C-terminal type-2 calponin homology (CH) domain. Often used preferred marker differentiated smooth cells, A B (SMTN-A SMTN-B) may influence potential cells. more recently identified (SMTNL1 SMTNL2) have diverse functional implications. SMTNL1 linked regulation contractility adaptations both skeletal hypertension, pregnancy, exercise training. suggested play multiple roles in through interactions with regulators (e.g., calmodulin, tropomyosin, myosin phosphatase) well transcriptional control phenotype Ca2+-sensitizing capacity. These effects are associated acute, reversible changes state or long-term mediated proteins. SMTNL2 remains essentially uncharacterized; however, its high could be differentiating myocytes. Finally, emerging opportunities exist understand significance smoothelins disease-associated markers some cases specific modulators pathophysiology.