Obesity and metabolic syndrome as risk factors for the development of non-alcoholic fatty liver disease as diagnosed by ultrasound.

摘要: Introduction/ aim. Non-alcoholic fatty liver disease (NAFLD) is a chronic of broad histological spectrum, characterized by the accumulation triglycerides in more than 5% hepatocytes the absence consuming alcohol quantities harmful to liver. The aim our study was determine importance anthropometric and laboratory parameters as well metabolic syndrome (MS) for diagnosis NAFLD estimate their influence on degree steatosis evaluated ultrasound (US). Methods. study included 86 participants, 55 whom had liver diagnosed ultrasound they comprised group. control group consisted 31 subjects. During course hospitalization at Clinic Gastroenterology Hepatology, Clinical Centre Nis, patients anamnesis taken, measurements as biochemical blood analyses abdominal were performed. Results. patients with statistically higher values body mass index (BMI), waist circumference (WC), systolic (SBP) diastolic pressure (DBP), levels alanin aspartate aminotransferase (ALT, AST), gamma-glutamyl transpeptidase (GGT) (p<0.001), low-density lipoprotein cholesterole (LDL), total bilirubin (TBIL) (p<0.05), cholesterol (p<0.01), (TGL), urates, C-reactive protein (CRP), ferritin, fibrinogenes, fasting glucose (FBG), insulin Homeostasis Model Assessment (HOMA-IR) whereas high-density lipoprotein cholesterol (HDL) group (p<0.05). In group, there significantly with hypertension (72.73% vs. 12.90%, p<0.001) type 2 diabetes mellitus (DM) (47.27%). Metabolic determined 48 (87.27%) An equal number patients, 16 them (29.09%), 3, 4 5 components MS. In 17 overweight (30.91%) (BMI from 25 kg/m2 29.9 kg/m2) 38 (69.09%) obese patients. (BMI ≥ 30.0 kg/m2). largest obesity 22 (40.00%) of them, first 30 34.99 The - 23 (41.82%), an finding grade 3 liver, 20 (36.36%) 12 (21.82%) 1 Kruskal-Wallis test ANOVA analysis showed significant differences between groups different US grade insulin, LDL-cholesterol, WC, BMI HOMA-IR body weight (BW) (p<0.01). present in grades (p<0.01) relation US finding, obesity, DM Conclusion. results have confirmed that high percentage risk factors (DM, MS, dyslipidemia, hypertension) NAFLD.