Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

作者: J. A. Johnston , M. J. Dalton , M. E. Gurney , R. R. Kopito

DOI: 10.1073/PNAS.220417997

关键词: Cytoplasmic inclusionBiologyAggresomeSuperoxide dismutaseCell biologyGenetically modified mouseAmyotrophic lateral sclerosisMutantInclusion bodiesNeurotoxicityBiochemistry

摘要: … appears to require their active transport on microtubules (16). … that is subject to retrograde transport on microtubules. This is … MT structure or transport in SOD transgenic mice in vivo, we …

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