Cortical reactivity in progressive myoclonus epilepsy
作者： Jari Karhu , Riitta Hari , Ritva Paetau , Matti Kajola , Esa Mervaala
DOI: 10.1016/0013-4694(94)90001-9
关键词: Myoclonus 、 Epilepsy 、 Cortex (anatomy) 、 Interstimulus interval 、 Medicine 、 Median nerve 、 Magnetoencephalography 、 Audiology 、 Auditory system 、 Progressive myoclonus epilepsy 、 General Neuroscience 、 Clinical neurology
摘要: Abstract We studied 4 patients with progressive myoclonus epilepsy (Unverricht-Lundborg disease; ULD). Somatosensory evoked fields (SEFs), auditory (AEFs), and spontaneous activity over the somatomotor cortex were recorded a 24-channel SQUID gradiometer. All had “giant” 20–45 msec median nerve SEFs at first cortex, 2–6 times larger amplitudes than healthy control subjects. Later deflections not similarly enhanced. The dependence of SEF on interstimulus interval (0.2–4 sec) successive ulnar-median stimulation (stimulus 40 msec) was comparable to that in controls. Cortical AEFs attenuated delayed. In 3 patients, consisted 6–8 Hz mu rhythm, which originated within 2 cm from sources abolished by clenching contralateral fist. Control subjects major spectral peaks around 10 20 Hz. strength 6–10 correlated strongly, suggesting some components obtain contributions overlapping neuronal populations. results imply ULD is associated thalamo-cortical hyperreactivity sensorimotor but system.
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