Intestinal hemorrhage from exposure to pulsed ultrasound

作者: Diane Dalecki , Carol H. Raeman , Sally Z. Child , Edwin L. Carstensen

DOI: 10.1016/0301-5629(95)00041-O

关键词: Ultrasound exposureUltrasoundPulse durationPulse repetition frequencyMedicinePulsed UltrasoundIntestinal HemorrhageIrradiationFrequency dependencePathologyNuclear medicine

摘要: Threshold exposures for producing intestinal hemorrhage in mice were determined using focused sources operating at 0.7, 1.1, 2.4 and 3.6 MHz. The choice of pulse length (10 μs) repetition frequency (100 Hz) made the diagnostically relevant, while same time, minimized possible thermal contributions to mechanism action ultrasound. Each animal was irradiated four five abdominal sites 5 min per site. Suprathreshold lesions ranged from small petechiae hemorrhagic regions extending 4 mm or more along intestine, depending upon exposure levels. Higher frequencies less effective than lower frequencies. Thermocouple measurements temperature rise intestine during ultrasound revealed increments between 1° 2°C highest dependence production together with observed limited heating is consistent a cavitation-related pulsed

参考文章(16)
Carol H. Raeman, Sally Z. Child, Diane Dalecki, Robert Mayer, Kevin J. Parker, Edwin L. Carstensen, Damage to murine kidney and intestine from exposure to the fields of a piezoelectric lithotripter. Ultrasound in Medicine and Biology. ,vol. 20, pp. 589- 594 ,(1994) , 10.1016/0301-5629(94)90095-7
S.Z. Child, C.L. Hartman, L.A. Schery, E.L. Carstensen, Lung damage from exposure to pulsed ultrasound Ultrasound in Medicine and Biology. ,vol. 16, pp. 817- 825 ,(1990) , 10.1016/0301-5629(90)90046-F
Douglas L. Miller, Ronald M. Thomas, Heating as a mechanism for ultrasonically-induced petechial hemorrhages in mouse intestine. Ultrasound in Medicine and Biology. ,vol. 20, pp. 493- 503 ,(1994) , 10.1016/0301-5629(94)90104-X
Michael R. Bailey, David T. Blackstock, Diane Dalecki, Carol H. Raeman, Sally Z. Child, Edwin L. Carstensen, Bioeffects of positive and negative pressure pulses in vivo Journal of the Acoustical Society of America. ,vol. 96, pp. 3305- 3305 ,(1994) , 10.1121/1.410829
Alice F. Tarantal, Don R. Canfield, Ultrasound-induced lung hemorrhage in the monkey. Ultrasound in Medicine and Biology. ,vol. 20, pp. 65- 72 ,(1994) , 10.1016/0301-5629(94)90018-3
E.L. Carstensen, S.Z. Child, C. Crane, M.W. Miller, K.J. Parker, Lysis of cells in Elodea leaves by pulsed and continuous wave ultrasound. Ultrasound in Medicine and Biology. ,vol. 16, pp. 167- 173 ,(1990) , 10.1016/0301-5629(90)90145-3
Douglas L. Miller, Ronald M. Thomas, Thresholds for hemorrhages in mouse skin and intestine induced by lithotripter shock waves Ultrasound in Medicine and Biology. ,vol. 21, pp. 249- 257 ,(1995) , 10.1016/S0301-5629(94)00112-X
R. Baggs, D.P. Penney, C. Cox, S.Z. Child, C.H. Raeman, D. Dalecki, E.L. Carstensen, THRESHOLDS FOR ULTRASONICALLY INDUCED LUNG HEMORRHAGE IN NEONATAL SWINE Ultrasound in Medicine and Biology. ,vol. 22, pp. 119- 128 ,(1996) , 10.1016/0301-5629(95)02035-7
Leon A. Frizzell, Ellen Chen, Chong Lee, Effects of pulsed ultrasound on the mouse neonate: hind limb paralysis and lung hemorrhage Ultrasound in Medicine and Biology. ,vol. 20, pp. 53- 63 ,(1994) , 10.1016/0301-5629(94)90017-5