Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants

摘要: Comparisons were made of branched vs unbranched saturated fatty acids and cis trans unsaturated as skin penetration enhancers primary irritants. Skin studies used naloxone base the diffusant, propylene glycol vehicle, human skin. Maximum flux was with C9–12-branched acids. For C5–14 acids, isomers had similar effects. One C18 acid isomer (C16-branched isostearic acid) more effective in enhancing than a differently (C2-branched or (stearic acid). There no significant difference between C16–18 their effects on flux, all corresponding isomers. Several these acid/propylene vehicles evaluated rabbit irritation test. Irritation indices poorly correlated effectiveness flux. It possible to enhance greatly vehicle only minimal potential.