Use of interferon-alpha in recurrent respiratory papillomatosis: 20-year follow-up.
作者： Valentin Gerein , Eugen Rastorguev , Johann Gerein , Peter Jecker , Herbert Pfister
DOI: 10.1177/000348940511400608
关键词: Prospective cohort study 、 Incidence (epidemiology) 、 Surgery 、 Medicine 、 Adjuvant therapy 、 Recurrent Respiratory Papillomatosis 、 Alpha interferon 、 Interferon alfa 、 Internal medicine 、 Clinical trial 、 Human papillomavirus
摘要: Objectives:The aim of this study was analysis the results use interferon-α (IFN-α) in patients with recurrent respiratory papillomatosis (RRP) and correlation human papillomavirus (HPV) type.Methods:A multicenter prospective series (42 from 22 hospitals) yielded 20 years follow-up RRP HPV typing who were treated IFN-α doses 3 MU/m2 times per week.Results:During long-term (mean ± SD, 172 36.8 months), rate event-free survival evaluated by Kaplan-Meier 42.8%, overall 82.6%. The revealed an association 11 a more aggressive disease course (64% versus 24% 6 patients), lower incidence response to therapy (14% 64% higher malignant transformation mortality during (36% 24%, respectively, 0% patients...
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