Which Factors Affect the Completion and Publication of Dental Implant Trials

摘要: Purpose Clinical decision making in implant dentistry may be vulnerable to industry influence. The purpose of this study was identify factors associated with the completion and publication trials. Materials Methods This a cross-sectional dental trials registered ClinicalTrials.gov . predictor variables were composed set characteristics including design (investigational or observational), topic, sample size (≤50 >50 participants), investigator specialty (periodontics, oral-maxillofacial surgery, prosthodontics, general/implantology, other), site (United States international), funding (yes no). outcome time publication. Reverse Kaplan-Meier analyses used determine time-to-event probabilities, Cox proportional hazards models Results A total 317 included final sample. median trial duration 2.3 years, from 1.9 years. Compared periodontist-led trials, oral maxillofacial surgeon–led had greater success (publication rate, 73.0% vs 54.4%; P = .01) but less likely conducted United (US present, 8.8% 46.0%; P  Conclusions Trials that funded lower rates not Future efforts should explore reasons for research waste improve US surgeon involvement clinical research.