P2X7 Receptors: An Untapped Target for the Management of Cardiovascular Disease.

摘要: Chronic low-grade inflammation contributes to the development of several diseases, including cardiovascular disease. Adequate strategies target in disease are their infancy and remain an avenue great interest. The purinergic receptor P2X7 is a ubiquitously expressed that predominately mediates cellular death. ligand-gated cation channel activated response high concentrations extracellular ATP, triggering assembly activation NLRP3 (nuclear oligomerization domain like family pyrin containing 3) inflammasome subsequent release proinflammatory cytokines IL (interleukin)-1β IL-18. Increased IL-1β IL-18 have been implicated many conditions hypertension, atherosclerosis, ischemia/reperfusion injury, heart failure. KO (knockout) mice exhibit significant attenuation inflammatory response, which corresponds with reduced severity. antagonism blunts blood pressure elevation hypertension progression atherosclerosis animal models. inhibition has shown efficacy clinical trials reducing major adverse cardiac events, myocardial infarction, With antagonists available proven safety margins, could represent untapped potential for therapeutic intervention disorders.