Design and synthesis of (S)- and (R)-α-(phenyl)ethylamine-derived NH-type ligands and their application for the chemical resolution of α-amino acids
作者： Ryosuke Takeda , Akie Kawamura , Aki Kawashima , Hiroki Moriwaki , Tatsunori Sato
DOI: 10.1039/C4OB00669K
关键词: Reagent 、 Chiral auxiliary 、 Amino acid 、 Ethylamine 、 Organic chemistry 、 Cost structure 、 Chemistry 、 Physical and Theoretical Chemistry 、 Biochemistry
摘要: This work presents the first chemical approach for resolution of α-amino acids offering following advantages: (1) The specially designed resolving reagent is derived from α-(phenyl)ethylamine, most inexpensive chiral auxiliary, which can be recycled and reused, rendering cost structure complete process very attractive; (2) time-efficient two-step conducted under operationally convenient conditions with virtually quantitative yields; (3) readily adapted to large-scale use.
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